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EVERYONE searches Reaxys and then one other database
EVERYONE keeps a log of their searches and results, even if the results are null
EVERYONE identifies the "best" source(s) they found and adds it to the class document
Dr. Walker moderates the results for next steps
Please see the lab handout for detailed requirements. The project overall calls for you to develop a viable lab procedure for the allylation of carvone.
Your Task for this Session:
Search the literature for allylation of carvone, which is likely to involve a two step process:
Formation of the enolate of carvone, by reacting carvone with LDA (or other strong base)
Reaction of that enolate with allyl chloride or allyl bromide (or something similar).
find methods to do this and determine the "most appropriate" (as defined by your professor) possibility.
Find the specific procedure you will use in lab to do this.
Researching chemical procedures
While there are many unique aspects to searching chemistry literature, the main process follows the flow of the general research process. For this lab, the specific tasks and the order in which you will cover them are listed in the tabs above. Namely:
1) Topic analysis on the reaction:
What general type of reaction is it?
What are the anticipated products? reactants?
What are the CAS numbers, inchi names, upac names, chemical formulary, chemical structures, etc. for the products and reactants? In other words, every synonomous way you can come up with for labeling them.
What other words or phrases are associated with the reaction, products, reactants,...
2) Types and selection of search tools:
By inputing chemical formulary
By text searching in:
Electronic book searching (or searching the index of suitable paper books)
The free web (google scholar...)
Finding article literature
3) Searching within the right tools and identifying specific articles/patents
4) Reading the abstracts to determine appropriateness and Selecting which articles to read
5) Locating or interlibrary loaning the full-text of the articles